Controlled Endolysosomal Release of Agents by pH-responsive Polymer Blend Particles

Controlled release of guest molecules from mesoporous silica particles based on a pH-responsive polypseudorotaxane motif.

Release of theophylline from polymer blend hydrogels.

Polymer blending is a simple yet attractive method to obtain combined physical and mechanical properties of polymers. In this paper, three types of blend hydrogels were prepared, each by physically blending two different natural polymers, and a model drug, theophylline (TPH), was immobilized into these hydrogels for the studies of drug release. The release profiles of TPH from various types of ...

Polymer Blend Emulsions Stabilized by Janus Particles KYLE

Submitted for the MAR13 Meeting of The American Physical Society Polymer Blend Emulsions Stabilized by Janus Particles KYLE BRYSON, THOMAS RUSSELL, RYAN HAYWARD, University of Massachusetts Amherst — Kinetic trapping of bicontinuous polymer morphologies through the interfacial segregation of nanoparticles is of interest due to the unique combination of the properties of each component provided ...

Surface Immobilization of pH-Responsive Polymer Brushes on Mesoporous Silica Nanoparticles by Enzyme Mimetic Catalytic ATRP for Controlled Cargo Release

Peroxidase mimetic catalytic atom transfer radical polymerization (ATRP) was first used to install tertiary amine-functionalized polymer brushes on the surface of mesoporous silica nanoparticles (MSNs) in a facile and highly efficient manner. Poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) brushes-grafted MSNs were fabricated by biocompatible deuteroheminβ-Ala-His-Thr-Val-Glu-Lys (DhHP-6)-c...

A pH-driven DNA nanoswitch for responsive controlled release.

An intelligent pH-responsive carrier and release system based on DNA nanoswitch-controlled organization of gold nanoparticles (AuNPs) attached to mesoporous silica (MS) has been designed and demonstrated.